Myopathy

Name 3 x-linked muscular dystrophy conditions

Histologically, in advanced cases muscle fibers are replaced by fibrofatty tissue in which condition

Which muscle type is more dependent on fat catabolism for energy through mitochondrial oxidative phosphorylation

EMG study of this condition showed electrical silence when the muscle is cooled

Besides muscle, which other tissue is dystrophin found in?

In this Autosomal recessive muscle dystrophy, patient has UE and LE proximal weakness and scattered fiber necrosis and regeneration seen on muscle biopsy

This 12 y.o boy c/o pain from muscle spasm, worse in the winter

Grouped muscle atrophy is a hallmark of which type of atrophy

Disuse- and steroid-induced atrophy primarily affects which TYPE fibers and causes a random distribution of the atrophic myofibers

Patient with this condition has Distal> proximal muscle weakness, frontal balding, hatchet face, cardiac endocrine abnormality

Patient with this condition can move eyes freely but has retinopathy, facial weakness, frontal balding, lip protrusion .

what are three x-linked Dystrophic Myopathies

This patient has difficulty getting up from a chair or climbing steps

What are three histolology features of Duchenne Dystropy

This sign describes a patient that has to use their hands and arms to "walk" up their own body from a squatting position due to lack of hip and thigh muscle strength.

Name a condition that affects the ability to breakdown Glycogen--> glucose

52 y.o man has painless progressive muscle weakness

This 60 y.o. with RA , developed progressive proximal muscle weakness but normal EMG. What is likely condition?

This person reports being "paralyzed" after exercise, but felt better after eating Oreos and crackers and chocolate

This patient is at risk formalignant hyperthermia due to absent of ---- in type 1 fibers

Name 2 conditions that could cause this.