How is he? - What should he do?
He is tired. He should take a rest.
How is he? - What should he do?
He is dirty, He should take a shower.
What's the matter with him? - What should he do?
His eye is hurt. He shouldn't play video games.
How is he? - What should he do?
He is fat. He should get exercise.
What's the matter with her? - What should she do?
She has a toothache. She shouldn't eat candy.