Study

Ischemic stroke

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  • DISCUSS immediate stroke management (not prevention/long term management)
    f
  • Diagnosis? tPA administration if within 75 minutes?
    Acute MCA infarct
  • Describe the utility and components of NIH stroke scale
    0 = no stroke; 1-4 minor; 5-15 moderate; 16-20 moderate-severe; 21-42 severe
  • Discuss prognosis & quality of life after stroke
    f
  • DRAW/DISCUSS clinical evaluation flow chart for a suspected stroke patient starting when they arrive at ED. What are you ruling out/confirming?
    Serum glucose = other causes of symptoms; non-contrast CT = ruling out hemorrhage for treatment; MRA = find arterial blockage; MRI = 
  • Define ischemic stroke
    cerebral infarction due to insufficient cerebral blood flow, resulting in ischemia and neuronal injury
  • Utility of cardiac telemetry and echocardiogram with bubble study
    cardiac telemetry = a fib (L sided clot -> embolus and stroke). Echo with bubble study - checking for PFO (clot on R side -> L side heart -> stroke)
  • Justify prescribing high-dose atorvastatin and short-term dual antiplatelet therapy with clopidogrel and aspirin (include MOA)
    Atorvastatin - HMG-CoA reductase inhibitor (inhibits cholesterol biosynthesis in the liver)
  • Moving home from college, I had a suitcase with all my clothes. When I picked it up from baggage claim, one of the zippers broke from the pocket with all of my underwear. I looked inside and someone had stuffed all of my underwear back in
    Alexa
  • Mr. Clooney had RUE and LUE paresis and LUE and LLE intact on neuro exam. What side of the brain was the stroke?
    Left! Contralateral side affected
  • tPA should not be administered for an ischemic stroke after how long?
    4.5 hours
  • T/F symptom onset is sudden
    F - typically onset over hours (compared to hemorrhagic stroke - sudden onset)
  • Diagnosis?
    Normal
  • What is the utility of a non-contrast CT in stroke management?
    Rule out hemorrhage - contraindication for tPA
  • Ischemic stroke accounts for __% of all strokes
    80-85%
  • Name 3 risk factors for ischemic stroke
    Age >65; hypertension; diabetes mellitus; atrial fibrillation; carotid artery stenosis
  • At a friends house in high school I heard meowing and released her kitten had snuck into the fridge. I laughed so hard I peed my pants. I was too embarrassed to tell them so I "accidentally" spilled my entire arizona tea in my lap to hide i
    Rae
  • Why is it important to order a CT prior to full clinical evaluation in a suspected stroke patient?
    Time is brain... save the penumbra! - Dr. West
  • What is the meaning of "Time is brain...save the penumbra!"
    Penumbra = area surrounding the ischemic event. If blood flow is restored quickly enough after a stroke, the penumbra can be preserved by collateral circulation
  • Discuss waiting to re-start lisinopril despite Mr. Clooney's BP remaining elevated
    Permissive HTN. Increased BP has better chance of getting blood through narrow blood vessels (he has stenosis of MCA)
  • WHO's WHO - I learned only a few years ago due to a rude awakening moment that pink lemonade was not actually made from pink lemons
    Sulaiman
  • Discuss mechanisms underlying neuronal injury during ischemic stroke
    Deprivation of ATP in cells -> dysfunction of Na/K ATPase -> build up of Na draws in water -> cytotoxic edema & inflammation; excitotoxicity (glutamate)
  • Relate risk factors to pathogenesis of ischemic stroke
    Smoking = toxin in tobacco damages endothelium -> atherosclerosis -> plaque obstructs arterial blood flow -> thrombotic stroke;
  • I took French in middle school. We were tasked to write a short story in English and then translate to French and present to the class. I read the English version with a French accent by mistake
    Alyssa
  • Discuss the types of ischemic strokes
    1. embolic (20%); 2. thrombotic (40%); 3. Global hypoxia (i.e. cardiogenic shock)
  • WHO's WHO - I wore heels toa first date and the parking lot was dark and I stepped in a hole and fell down and tore my jeans and showed up to my first date with a skinned knee
    Kristen
  • Contraindications for tPA use
    Recent ischemic stroke; GI malignancy or recent bleed; severe uncontrolled hypertension; nondisabling minor stroke (NIHSS <5)
  • What does the acronym FAST stand for?
    Facial drooping; arm weakness; speech difficulties; time
  • Diagnosis? tPA administration if this was taken within 3 hours of arrival?
    Acute left MCA distribution hemorrhagic infarction. NO! contraindicated with hemorrhage.
  • Describe the RACE stroke scale - utility and components
    Facial palsy; arm motor function; leg motor function; head and gaze deviation. If R hemiparesis - test aphasia; if L hemiparesis - test agnosia
  • WHO's WHO - I got into a car accident the day after I got my license
    Vincent
  • Damage from ischemic stroke depends on
    location and time!