Is he angry?
No, he is not.
Is he sad?
Yes, he is
Is she tired?
No, she is not.
Is he happy?
Yes, I am; no I'm not
Is she tired?
No, she isn't
Is he tired?
Yes, he is.
Is he hungry?
No, he isn't
Is he hungry?
No, he isn't
Is he tired?
No, I'm not/yes, I am
Is she hot?
No, he isn't
Is she hungry?
Yes, she is.