What problem is this?
It's travel sick(ness).
What problem is this?
It's stomach ache. / It's an upset stomach.
What is the matter? What should she do?
---
What has happened to this woman? What should and shouldn't she do?
---
What's wrong with him? What can he do?
---
What problem is this?
It's a sprained ankle.
What problem is this?
It's a runny nose.
What's the matter?
He has a headache.
How is she feeling? What should the driver do? What is best for her?
---
What is wrong with her? What should and shouldn't she do?
---
What's the matter with him? What should he do?
---
What's the matter? What should she do? What shouldn't she do?
---
What's the matter? What should he do?
---
What problem is this?
It's a sore throat.
What problem is this?
It's hay fever.
What problem is this?
It's toothache.