When would you use IV fluid repletion over oral
Severe hypovolemia
Differentiate clinical presentation viral v. bacterial gastroenteritis
Viral (specifically norovirus) primary symptom is vomiting
GUESS WHO - ____ ran into a glass wall in front of everyone at a fancy restaurant because the glass was so clean
Andrew
GUESS WHO - ____ had a presentation in front of an important person and finished the presentation to find their sons spit up all over their suit
Dr. LoCurto
Pathogenesis of gastroenteritis (specifically E. coli)
fecal-oral transmission -> adhesions (CF) to attach to intestinal epithelium -> disrupts absorptive and secretory properties of mucosal epithelium -> diarrhea
GUESS WHO - ______ called their teacher "mom" in middle school in front of the class
Alyssa
Prevention of gastroenteritis
Proper HYGIENE! Fully-cooked foods; water purification
Use of PCR analysis in Dx/treatment
More accurate pathogen identification for targeted treatment
Differentiate mild, moderate, and severe gastroenteritis clinical presentations
Mild - diarrhea is tolerable; Moderate - distressing, interferes with plans; severe - incapacitating, completely prevents plans
GUESS WHO - ___ fell asleep in STRX and woke up as the only student in the main room with the facilitators (breakout rooms)
Sarah
GUESS WHO - At a bar, ___significant other rubs Dominic Monaghan's hair and exclaimed "you are so short!"
Charles
What is occurring at the crypt cells
Contain channels for Cl- secretion (responds to increases in cAMP)
MOA of ondansetron
*
Enterotoxicogenic E. coli virulence factors
Adhesions (colonizing factor) and Exotoxins (heat-labile toxin -> increase Cl- secretion & heat-stable toxin - decrease reabsorption NaCl and H20)
GUESS WHO - _____ pointed confidently to the vertebrae on the cadaver when Dr. B asked where the trachea was
Sandhya
MOA of oral rehydration therapy
Intestinal glucose absorption via sodium-glucose cotransport remains intact. Intestine can absorb water if glucose and salt are also present to transport water
GUESS WHO - ___ got "pantsed" in the middle of Macys, showing everyone their underwear
Astrid
Differentiate secretory and osmotic diarrhea
Secretory - excess secretion of electrolytes and water; osmotic - excessive solutes in intestine causing water to not be reabsorbed
Subclass of Ondansetron
Antiemetic; selective 5-HT3 receptor antagonist
Enterotoxigenic E. coli causes inflammation T or F
FALSE
Significance of stool sample
Causative organism (viral v. bacterial, etc.)
S. boulardii is a bacterial probiotic - T or F
FALSE - yeast