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action potential blocking disorders

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  • blocks adenosine receptors in the brain's arousal system
    caffine
  • Fugu, made from pufferfish, edible only if poison is removed, Japanese delicacy
    tetrodotoxin
  • blocks voltage-gated Na+ channels
    tetrodotoxin
  • inhibits release of ACh, used medically for cervical dystonia
    botox
  • ACh degradation is blocked, muscle continues to contract causing paralysis
    nerve gas
  • blocks re-uptake transporters for dopamine, norepinephrine and serotonin
    cocaine
  • starts with spastic paralysis but ends with flaccid paralysis
    nerve gas
  • active ingredient is tubocurarine, used in blow darts to paralyze prey
    Curare
  • neostigmine, physostigmine
    myasthenia gravis treatment
  • toxin cleaves SNARE protien
    botox/botulism
  • I can't feel my face, am I smiling?
    botox
  • Russian spy and avenger
    black widow
  • there is no antidote to this toxin, can cause paralysis and asphyxiation
    tetrodotoxin
  • Block voltage gated channels on sensory neurons- local anesthesia
    "caines"
  • binds to and blocks ACH receptors, relaxes skeletal muscle
    curare
  • treatment for severe underarm sweating and facial wrinkles
    botox
  • nicotinic ACh receptors are inhibited by
    curare
  • Don't eat the pufferfish it's poisonous!
    tetrodotoxin
  • triggers explosive release of ACh from storage vesicles at the NMJ and cholinergic sites
    black widow venom
  • Inhibits ACh esterase activity
    nerve gas and pesticides
  • can cause nausea, camps, lack of coordination and difficulty breathing; death can occur from respiratory failure
    black widow venom
  • antibodies block and destroy ACh receptors
    Myasthenia gravis
  • blepharospasm and strabismus treatment
    botox
  • produced by the bacterium Clostridium botulinum
    botulism
  • causes flaccid paralysis
    botulism/botox
  • causes muscle paralysis by blocking voltage gated Na+ channels
    tetrodotoxin
  • progressive weakening of skeletal muscles
    myasthenia gravis
  • often used in drugs that are used during surgery
    curare
  • prolonged use decreases overall synthesis of dopamine
    cocaine
  • botulinum toxin inhibits release of ACh at the neuromuscular junction
    botulism
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