What's the matter with you?
I have a fever / temperature.
What's the matter with him?
He has a toothache.
What's wrong with her?
She has a cold.
What's the matter with him?
He has a stomachache.
What's wrong with her?
She has a headache.
What's the matter with him?
He has an earache.
What's the matter with her?
She has a broken arm.
What's the matter with you?
I have a sore throat.
What's wrong with her?
She has a cough.
What's wrong with him?
He has a broken leg.
What's the matter with him?
He has a backache.