What is the function of GTPase-activating proteins?
(GAPs) drive the proteins into an “off” state by increasing the rate of hydrolysis of bound GTP.
Any one ligand for nuclear receptor
Steroid hormones, Thyroid hormones, Retinoid etc
Which two sub-units of G protein are linked to plasma membrane?
α and γ.
Which protein binds PKA to the cytoskeleton ?
A kinase anchoring protein (AKAP)
What is the function of loops of GPCR on cytosolic side of plasma membrane?
Binding site for G protein/Arrestin
Give an example of enzyme that brings about phosphorylation
Kinases
What is the total number of subunits present on cAMP dependent protein kinases (PKA)?
4
Full form of GPCR
G proteinn coupled receptor
Binding of ________ α subunit dissociates from trimmer of G protein
GTP
How many times polypeptide of GPCR intervene plasma membrane ?
7