What is the matter? What should she do?
Allergy
What's the matter with him? What should he do?
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What's the matter?
He has a headache.
What problem is this?
It's toothache.
What's the matter? What should he do?
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What's the matter? What should she do? What shouldn't she do?
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What problem is this?
Sneezing / fever / allergy
What problem is this?
It's stomach ache.
What's wrong with him? What can he do?
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