What's the matter with her?
She has a sore throat.
What's the matter with him?
He has a stomachache.
What's the matter with her?
She has a cough.
What's the matter with him?
He has a broken arm.
What's the matter with her?
She has a toothache.
What's the matter with him?
He has a cold.
What's the matter with him?
He has an earache.
What's the matter with him?
He has a broken leg.
What's the matter with him?
He has a temperature/fever.
What's the matter with her?
She has a flu.
What's the matter with him?
He has a backache.
What's the matter with her?
She has a headache.