He isn’t flying out of O’Hare Airport. (What?)
What airport is he flying out of?
Oscar isn’t going to New York City. [Where?]
Where is Oscar going?
She isn't flying out of Benito Juárez airport. (What?)
What airport is she flying out to?
He isn’t flying with American. [What?]
What airline is he flying with?
Alma isn't going to Los Angeles. (Where?)
Where is she going to?
The plane isn’t coming from Los Angeles. [What?]
What city is the plane coming from?
He isn’t flying into JFK. [Which?]
Which airport is he flying into?