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Human REPAIRome - consolidation activity

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  • The article states that DNA "scars" are also known as a "mutational __________."
    footprint
  • What clinical problem does REPAIRome target?
    Tumor resistance to therapy
  • The team discovered a new pattern of mutations related to kidney cancer and to __________ (low oxygen) conditions in other tumors.
    hypoxic
  • True or False: The REPAIRome is expected to help improve antibiotic development.
    False
  • True or False: Cancer treatments often stop working because tumor cells learn to repair the DNA breaks caused by the therapy.
    True
  • True or False: The "human REPAIRome" is a new type of cancer drug designed to cause DSBs.
    False
  • True or False: A key technological advance was the ability to analyze all 20,000 cell populations simultaneously instead of one by one.
    True
  • The scar patterns, which take the form of insertions and deletions, are also referred to by the acronym __________.
    indels
  • What do specific DNA scars infer?
    Which genes are not working
  • What is the researchers' organization (acronym)?
    CNIO
  • To create the breaks, the researchers used __________ gene-editing technology.
    CRISPR
  • According to the researchers, understanding a tumor's scar pattern could help determine the best treatment for that cancer.
    True
  • Name two causes of DSBs.
    X-rays and sunlight/UV radiation
  • The REPAIRome specifically addresses the repair of __________ (DSBs), which are considered one of the most serious types of DNA damage.
    DNA double-strand breaks
  • True or False: The human REPAIRome data is a proprietary resource available only to researchers at CNIO.
    False
  • To study the effect of each gene, researchers generated 20,000 cell populations, each with a different single gene __________.
    disabled
  • True or False: The article suggests that DSBs are only caused by external factors like X-rays and UV radiation.
    False
  • True or False: A DNA double-strand break (DSB) occurs when only one of the two strands of the DNA helix is broken.
    False
  • The new resource created by the CNIO researchers, which catalogs 20,000 types of DNA repair scars, is called the human __________
    REPAIRome
  • True or False: The "scars" left behind by DNA repair are random and do not provide any useful information about the repair process.
    False
  • The CNIO team was led by Dr. __________, head of the DNA Topology and DNA Breaks group.
    Felipe Cortés-Ledesma
  • The research paper on the REPAIRome was published in the journal __________.
    Science
  • Many existing cancer therapies, such as radiation, work by __________ DSBs in tumor cells.
    causing
  • What is a DNA "scar"?
    A mutational footprint (left by repair)
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