Study

PHT231-Lecture 1

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  • When a poorly water-soluble drug is dispersed into an inert hydrophilic polymeric matrix at molecular level. This is called.........
    Solid dispersion
  • How can you prepare solid dispersion?
    several methods such as melting , kneading
  • ....................... is the solubilization of a drug by the addition of large amount of sodium benzoate
    Hydrotropy
  • How cyclodextrins are prepared?
    By enzymatic degradation of starch
  • What is the meaning of inclusion complexation?
    Cyclodextrins (CDs) are cyclic oligosaccharides composed of six or more α-1,4-linked glucose units. CDs possess a hydrophilic exterior and a hydrophobic interi
  • The solubility of poorly soluble drugs in water can be increased by mixing it with some water miscible solvent in which the drug is readily soluble is called............
    Co-solvency
  • Give an example of a polymer used in the preparation of solid dispersion
    polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPMC), and polyethylene glycol 6000 (PEG6000).