Rheumatoid disorders (Joint disease)

male, age (40-60), AA & white, obesity, diet, genetics, medications, and medical conditions (htn, kidney disease, metabolic disorders and certain cancers)

morning stiffness, functional disability, pain, malalignment of fingers, crepitus

serum RF+, anti-ccp+, crp+, esr+, ana+, rbc reduced (anemia), C3 C4 reduced

gout and osteoarthritis

Inter-critical Gout - this happens after the gout attack subsides, no symptoms, remission period can last from weeks to years

Pannus formation

gender, age (females 40-50) males (36-80s), genetics, smoking, obesity, periodontitis, early life exposure

serum uric acid levels, 24 hour urine collection, x-ray imaging, polarized light microscopy of synovial fluid, (which gives a definitive diagnosis).

great toe, middle ear and hands

weight-bearing joints mainly, no

Rheumatoid Arthritis, Systemic Lupus Erythematous, & Scleroderma

x-ray to show joint and bone deterioration, synovial biopsy (inflammatory cells), arthrocentesis (abnormal synovial fluid)

acute gouty arthritis - gout attack, excruciating pain, build up of crystals in joint, attack will subside on it's own

Chronic Tophaceous Gout - see tophi buildup

pain gets worse with rest, gets better with activity

Joint pain, swelling, warmth, lack of function, morning stiffness over a hour, deformities to hands, wrists & feet, extra-articular disease manifestations

stop inflammation, remission, relieve symptoms, prevent joint and organ damage, improve functional ability, reduce long-term complications

synovial proliferation and tenderness in multiple joints

Pain management, rest & elevate, ICE, hydration, and diet education

age, obesity, genetics, joint location, malalignment of joint, trauma, gender

H&P, blood work, radiographic assessment like a MRI, synovial fluid analysis, arthroscopy (the gold standard)

asymptomatic hyperuricemia - no gout is manifested yet, asymptomatic, serum urate levels are high

Erosion + Hypertrophy

breaks down the cartilage of the joints