What's the matter?
He has a headache.
What's the matter?
She/He has a runny nose.
What's the matter?
He has a cough.
What's the matter?
She has a sore throat.
What's the matter?
She has a toothache.
What's the problem?
She has an earache.
What's the matter?
She/He has the flu/a cold
What's the problem?
He has a high temperature.
What's the problem?
She/He has a backache.
What's the matter?
She/He has a rash.