What's the matter with that girl?
She's got a cold.
What are they doing?
They are playing football.
What's the matter with her?
She's angry.
What are they doing?
They are playing tag.
What's the matter with her?
What's the matter with him?
He's got toothache.
What's the matter with him?
He's got a temperature.
What's the matter with her?
She's tired/sleepy.
What is she playing?
She's playing hopscotch.
What's the matter with him?
He's sad.
What's the matter with that boy?
He's got a cut.
What's the matter with her?
She's got a stomach-ache.
What's the matter with him?
He's got headache.
What's the matter with him?
He's got earache.