What's the matter with you?
I have a headache
What's the matter with you?
I have a toothache
What's the matter with him?
He has a fever.
What's the matter with her?
She has an earache.
What's the matter with him?
He has a backache.
What's the matter with you?
I have a sore throat
What's the matter with you?
I have a stomach ache.