What's the matter with him?
He's got a cold. (a cold)
What's the matter with her?
She's got a headache. (a headache)
What's the matter with her?
She's got a cut. (a cut)
What's the matter with her?
She's got a cough. (a cough)
What's the matter with him?
He's got earache. (earache)
What's the matter with him?
He's got a stomach-ache. (a stomach-ache)
What's the matter with her?
She's got a temperature. (a temperature)
What's the matter with him?
He's got toothache. (toothache)