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cardiovascular drugs

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    mechanisms of action
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  • These drugs block the effect of sympathetic nerves to cause vasoconstriction of blood vessels.
    alpha blockers
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  • Sometimes these drugs are referred to as sympatholytic because they opposes the downstream effects of organs innervated by the sympathetic nervous system.
    alpha blockers
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  • Drugs that block  α1-adrenergic receptors; this results in vasodilation, which results in the  lowering arterial blood pressure.
    alpha blockers
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  • drugs that block beta-adrenergic receptors; this  prevents norepinephrine (noradrenaline) and epinephrine (adrenaline) from stimulating these receptors.
    beta blockers
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  • Drugs that block β1 receptors decrease heart rate and force of contraction resulting in a reduction of cardiac output and blood pressure.
    beta blockers
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  • directly relaxing arteriolar smooth muscle by decreasing the phosphorylation of smooth muscle myosin light chain; this lowers arterial blood pressure by promoting arteriolar vasodilation and reducing TPN.
    Drugs that directly relax arteriolar smooth muscle (for example, hydralazine).
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  • block the release of norepinephrine from sympathetic endings; lowers blood pressure by preventing this vasoconstrictor effect.
    Drugs that block release of norepinephrine from sympathetic endings (for example, guanethidine).
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  • Drugs that act on the medulla oblongata to reduce sympathetic output; lowers B/P by preventing the effect of sympathetic activity and promoting arteriolar vasoconstriction.
    central-acting agents that act on the brain(medullar oblongata)to reduce sympathetic output (for example, clonidine).
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  • This type of drug blocks calcium channels reducing the entry of calcium into myocardial cells and smooth muscle cells of arteriole blood vessel walls. This results in lower BP.
    calcium channel blockers
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  • In the contractile cells, this type of medication primarily blocks L-type voltage gated calcium channels. TPR and BP are decreased as a result of reduced arteriolar smooth muscle contractile activity
    calcium channel blockers
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  • Grapefruit juice is contraindicated when taking this type of medication because it can increase the amount of medicine that enters your blood stream. As a result, your blood pressure can drop very suddenly.
    calcium channel blockers
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  • drugs that inhibit angiotensin-converting enzyme which converts angiotensin I to angiotensin II. when angiotensin I is not converted to angiotensin II,  blood pressure is lowered
    ACE inhibitor
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  • drugs that inhibit the release of aldosterone- when aldosterone is not released, the kidneys do not reabsorb sodium, blood volume is decreased, decreasing blood pressure.
    ACE inhibitor
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  • drugs that inhibit the release of ADH by the posterior pituitary which will decrease absorption of water at the kidneys decreasing blood volume and thus BP.
    ACE inhibitor
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  • drug that inhibits the body’s thirst center within the hypothalamus which causes a person to drink more -increased fluid intake causes an increase in blood volume and BP.
    ACE inhibitor
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  • blocks angiotensinII receptors prevent angiotensin II from activating the following activities and thus lower blood pressure.
    Drugs that block angiotensin II receptors (for example, losartan).
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