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What stimulates the primary immune response in blood?
Exposure to antigen
What does the antibody screen test for?
alloantibodies
What temperature does IgM react best at?
Room Temp 20-22 degrees C or lower
What does sensitized mean?
Immunoglobulin or complement attached to cell
What is the immediate spin phase?
Immediately following centrifuging room temp
What phase of testing used IgG sensitized RBC's?
Antiglobulin testing
Part of daily QC in blood bank laboratory is the testing of reagent antisera with corresponding antigen positive and antigen negative red cells. What does this procedure ensure?
Antibody specificity and potency
Why are group O red cells used as a source for commercial screening cells?
ABO antibodies do no react with group O
What characteristic is associated with polyspecific AHG?
It contains antibody specificity for IgG and C3d
What source of antibody is selected to determine the specificity of a red cell antigen in a patient sample?
Commercial antisera
Where is a gene in a 'cis' position located?
On the same chromosome
What information is provided by hemagglutination testing for red cell antigens?
Phenotype
What term is used when red cells with the genotype MM react stronger with anti-M, than red cells with genotype MN?
Dosage effect
What is the term that describes the expression of most blood group inheritance?
Autsomal co-dominant
What is zeta potential?
Force of repulsion between RBC's
Does temperature of reaction affect agglutination? What temp do we find clinically significant reactions?
Yes, clinically significant reactions occur at 37C
