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Coordination and response CIE A Level Biology re ...

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    Coordination and response CIE A Level Biology revision
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  • Explain the events in the presynaptic neuron at the neuromuscular junction starting with the arrival of an action potential
    diffusion of Ca2+ into neuron causes movement of vesicles containing acetylcholine which diffuses across the synapse to fuse with the presynaptic membrane
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  • What happens after acetylcholine diffuses into the synaptic cleft?
    it binds with receptors on the sarcolemma causing Na+ channels to open and Na+ to diffuse in and depolarise the membrane and initiate an action potential
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  • What happens in the muscle fibers after the action potential is initiated?
    depolarisation spreads down the T-tubules, channel proteins for Ca2+ open and Ca2+ ions diffuse out of the SR, bind to troponin
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  • Once Ca2+ binds to troponin what happens to allow muscle contraction?
    Troponin tropomyosin moves to expose myosin binding sites on the actin filaments, myosin heads form cross-bridges with thin filaments and the sarcomere shortens
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  • What type of fibers are found in the A band?
    myosin and actin
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  • What type of fibers are found in the H band?
    Only myosin
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  • What type of fibers are found in the I band?
    Only actin
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  • Where is the Z band?
    In the middle of the I band
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  • Describe the structure of myosin
    fibrous protein molecules anchored at the M line of a sarcomere each containing globular heads which point away from the M line
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  • Describe the structure of actin?
    globular protein molecules linked to form a chain which wrap to form a helical shape; tropomyosin is twisted around the two chains and troponin is also present
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  • Why are muscle fibers not usually referred to as cells?
    they are multinucleate
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  • What is the name of the endoplasmic reticulum of the muscle
    sarcoplasmic reticulum
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  • What impact does the action potential have on the sarcoplasmic reticulum?
    it opens calcium ion channels on the SR which causes calcium ions to floor the sarcoplasm.
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  • What causes the conformational change in the troponin-tropomyosin complex
    calcium ions attach to troponin
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