What problem is this?
It's toothache.
What's the matter?
He has a headache.
How is she feeling? What should the driver do? What is best for her?
?
What is the matter? What should she do?
?
What is wrong with her? What should and shouldn't she do?
?
What has happened to this woman? What should and shouldn't she do?
?
What's the matter with him? What should he do?
?
What's wrong with him? What can he do?
?
