What therapy uses autologous T-cells engineered to express a specific T-cell receptor that makes the T cells recognize tumor cells and destroy them?
CAR battery therapy
CAR T-cell therapy
CAR B-cell therapy
T-cell battering therapy
Which statement about CAR T-cell therapy is FALSE?
It creates immediate graft versus host disease
Useful in treating chemo refractory disease
Can be used independent of or in addition to a BMT
CAR T-cells can be directed to specific antigens
Which of the following conditions are NOT treated with CAR T-cell therapy?
Aplastic anemia
Acute Lymphoblastic Leukemia
Multiple Myeloma
Lymphoma
Where do the T-cells come from that are engaged in BiTE therapy?
They are harvested from actual bite wounds
The patient's own T-cells
A friend of a friend's T-cells
A donor's T-cells
Patients that receive immune effector cell therapy are most at risk for which 2 serious side effects?
Cytokine Restraint Sickness & nephrotoxicity
Sickle cell conversion & myeloablation
There are NO side effects.
Cytokine Release Syndrome & neurologic toxicities
What is the BEST thing a nurse can do to recognize and intervene for IEC related adverse effects?
Infrequent assessments with CRP and ICAN'T screening tools.
Frequent assessments with CRS & ICE/ICANS screening tools.
Remind the attending physician every hour to assess the pt.
Facebook thoughts and prayers.
A patient has completed IEC therapy. Their VS are: T - 99.1*F, P 96, BP 104/70, O2 sat 98% on RA. Grade the CRS.
Grade 6
Grade 0
Grade 2
Grade 4
A patient completed IEC therapy 4 days ago. Their VS are T - 101*F, P 112, BP 100/56, O2 Sat 93% on 2L via NC. Grade the CRS
Grade 4
Grade 1
Grade 0
Grade 2
The nurse is completing the ICE assessment on a patient that has received IEC therapy. What is a "perfect" ICE score?
50
10
1
100
The nurse is completing the ICE assessment on a patient that has received IEC therapy. Abnormals: patient states the year is 2016, they identify 2 out of 3 objects correctly and they can't count backwards from 100. What is their ICE score?
3
10
1
7
The nurse is completing the ICE assessment on a patient that has received IEC therapy. The patient does not get a perfect score. What does the nurse do NEXT?
Ask the medical student to round on this patient 1st.
Complete the ICANS assessment by assigning a grade.
Reorient the patient and reassess after coaching them.
Wait 6 hours and rescreen the patient.
The nurse completes the ICE assessment and the patient scores 7. The patient awakens spontaneously and has no seizures or other notable neurologic deficits. What grade is their ICANS?
Grade 2
Grade 0
Grade 1
Grade 3
The nurse completes the ICE assessment and the patient scores 3. The patient awakens to light sternal rub and has no seizures or other notable neurologic deficits. What grade is their ICANS?
Grade 2
Grade 4
Grade 3
Grade 10
Prior to the administration of CAR T therapy, the facility must have at LEAST ___ doses of Tocilizumab available.
2
12
4
1
A patient that has received CAR T therapy has a CRS grade of 2 (temp 100.9*F, BP 88/48) and is not responding to the 2nd 1000 mL fluid bolus. Which orders would the nurse anticipate?
Give a 3rd bolus and ibuprofen.
Give steroids and turn down the infusion.
Give tylenol & tocilizumab, transfer to ICU for vasopressors
Continue to monitor the patient.
A patient that has received CAR T-cell therapy today asks the nurse when they can drive again. Which answer by the nurse is correct?
"As soon as the benadryl wears off"
"Never"
"At least 8 weeks"
"At least 4 months"
