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What is Virchow's triad?
hypercoagulability, stasis, and endothelial injury
What is the scoring tool for VTE prophylaxis?
Padua
What are the 3 guidelines used for anticoagulation?
CHEST, NICE, ASH
Which DOAC is contraindication if CrCl >95 mL/min?
edoxaban
Which DOAC is recommended if CrCl < 15 mL/min?
apixaban
What criteria screening tool is used for DVT and PE?
Wells'
What is CHADSVASc and the associated scores for each risk factor?
*see picture*
In stroke prevention in afib, when would warfarin be indicated over a DOAC?
valvular afib (defined as moderate to severe mitral stenosis or mechanical heart valve)
What is the scoring tool in stroke prevention in afib to assess risk of major bleeding for patients on anticoagulation/
HAS-BLED
What are the 4Ts for HIT?
degree of thrombocytopenia, timing of platelet count, thrombosis of other sequelae, and other causes of thrombocytopenia
In HIT, what complex does the antibody recognize?
complex of PF4 and heparin
What are the two types of HIT? Which one is clinically important?
Type I and II; Important: Type II
What agents are non-heparin anticoagulants for HIT?
argatroban, bivalirudin, fondaparinux, and DOAC (apixaban or rivaroxaban but are off label use), warfarin
All DOACs are a substrate of ______
P-glycoprotein
What CYP enzyme are apixaban and rivaroxaban metabolized by?
CYP3A4
What are the two classifications of venous thromboembolism?
DVT and PE
