Identify a physiologic rationale for the declining efficacy of carbidopa-levodopa treatment over time in PD.
d
Oops!
Check
Okay!
Check
seesaw
Swap points!
Oops!
gift
Win 25 points!
Okay!
fairy
Take points!
5
10
15
20
25
baam
Lose 20 points!
Oops!
15
Identify two subclasses of sedative-hypnotics to treat insomnia. Include MOA
f
Oops!
Check
Okay!
Check
15
What is the MOA of the first-line Alzheimer disease treatment
Donepezil - cholinesterase inhibitor - Boost the amount of ACh in the brain -> higher ACh in synapse, more likely to have a signal -> improve symptoms of dement
Oops!
Check
Okay!
Check
15
Identify the MOA of the six different drug therapies used to manage PD symptoms
COMT inhibitor (Tolcapone)) and MAO-B inhibitor (Selegiline) ->
Oops!
Check
Okay!
Check
15
What is the first-line treatment for anxiety disorders
g
Oops!
Check
Okay!
Check
15
Outline how cannabinoids would alter action potentials to improve MS-related spasticity.
Cannabinoids decrease the release of pre-synaptic glutamate-> decrease the amplitude of EPSPs-> decrease excitability of motor pathway in CNS ->
Oops!
Check
Okay!
Check
15
Explain the rationale for the use of fosphenytoin for seizure prophylaxis following TBI
Anticonvulsant - stabilize neuronal membranes & decrease seizure activity by increase efflux/decrease influx Na+ across cell membrane during generation nerve im
Oops!
Check
Okay!
Check
15
What is the MOA of the second-line Alzheimer disease treatment
Memantine - NMDA receptor blocker - decreases effects of glutamate (known to cause neuronal toxicity)
Oops!
Check
Okay!
Check
15
Justify the use of tPA in ischemic stroke
Alteplase
Oops!
Check
Okay!
Check
15
Justify the use of diuretics in the treatment of Meniere's disease
Theoretically improves symptoms by reducing the endolymph volume but high-quality studies on the effect of diuretics are lacking
Oops!
Check
Okay!
Check
15
Rationalize the use of mannitol in acute TBI
reduce ICP by reducing blood viscosity -> increases cerebral blood flow and oxygen transport and constricts pial arterioles -> reduce cerebral blood volume, ICP
Oops!
Check
Okay!
Check
banana
Go to last place!
Oops!
star
Double points!
Okay!
fairy
Take points!
5
10
15
20
25
banana
Go to last place!
Oops!
15
Distinguish abortive and preventative pharmacotherapies for migraine headache.
