Unit 8 drugs | Baamboozle - Baamboozle | The Most Fun Classroom Games!

Justify the use of tPA in ischemic stroke

Alteplase

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Justify the use of diuretics in the treatment of Meniere's disease

Theoretically improves symptoms by reducing the endolymph volume but high-quality studies on the effect of diuretics are lacking

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Explain the rationale for the use of fosphenytoin for seizure prophylaxis following TBI

Anticonvulsant - stabilize neuronal membranes & decrease seizure activity by increase efflux/decrease influx Na+ across cell membrane during generation nerve im

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Distinguish abortive and preventative pharmacotherapies for migraine headache.

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What is the MOA of the first-line Alzheimer disease treatment

Donepezil - cholinesterase inhibitor - Boost the amount of ACh in the brain -> higher ACh in synapse, more likely to have a signal -> improve symptoms of dement

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Identify two subclasses of sedative-hypnotics to treat insomnia. Include MOA

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seesaw

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gift

Win 10 points!

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fairy

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lifesaver

Give 20 points!

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heart

Other team wins 5 points!

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rocket

Go to first place!

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rocket

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baam

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What is the first-line treatment for anxiety disorders

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Identify the MOA of the six different drug therapies used to manage PD symptoms

COMT inhibitor (Tolcapone)) and MAO-B inhibitor (Selegiline) ->

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Identify a physiologic rationale for the declining efficacy of carbidopa-levodopa treatment over time in PD.

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Outline how cannabinoids would alter action potentials to improve MS-related spasticity.

Cannabinoids decrease the release of pre-synaptic glutamate-> decrease the amplitude of EPSPs-> decrease excitability of motor pathway in CNS ->

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monster

Reset all scores!

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fairy

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gift

Win 25 points!

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baam

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trap

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fairy

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gift

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baam

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What is the MOA of the second-line Alzheimer disease treatment

Memantine - NMDA receptor blocker - decreases effects of glutamate (known to cause neuronal toxicity)

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Rationalize the use of mannitol in acute TBI

reduce ICP by reducing blood viscosity -> increases cerebral blood flow and oxygen transport and constricts pial arterioles -> reduce cerebral blood volume, ICP

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