• Unit 8 drugs
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  • Rationalize the use of mannitol in acute TBI
    reduce ICP by reducing blood viscosity -> increases cerebral blood flow and oxygen transport and constricts pial arterioles -> reduce cerebral blood volume, ICP
  • Explain the rationale for the use of fosphenytoin for seizure prophylaxis following TBI
    Anticonvulsant - stabilize neuronal membranes & decrease seizure activity by increase efflux/decrease influx Na+ across cell membrane during generation nerve im
  • Identify the MOA of the six different drug therapies used to manage PD symptoms
    COMT inhibitor (Tolcapone)) and MAO-B inhibitor (Selegiline) ->
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