Summarize the two main roles of vWF in the process of clot formation
1.primary hemostasis- PLT adhesion; 2.secondary hemostasis- vWF complexes VIII->prolong half-life VIII (prevent its degradation)->complex IX->activate X
Oops!
Check
Okay!
Check
lifesaver
Give 25 points!
Oops!
magnet
Take 15 points!
Okay!
gift
Win 20 points!
Okay!
thief
Give points!
5
10
15
20
25
15
Describe the DNA damage that occurs from ultraviolet (UV) radiation and explain how this damage can lead to cancer
UVB causes thymine base pairs to bind to each other->pyrimidine dimers; UVA->ROS=damage DNA repair proteins=cancer
Oops!
Check
Okay!
Check
15
Discuss how Protein S and C work and their relevance in evaluating thrombophilia
Proteins S & C work together to prevent your blood from clotting too much; if low S&C = clot too much; P&C inactivate factors V/VIII = slow down clot formation
Oops!
Check
Okay!
Check
15
why do patients with Ewing sarcoma present with generalized pain?
immune cells trigger inflammation->cytokines->inflammatory markers->activate nociceptors throughout body
Oops!
Check
Okay!
Check
15
What is the underlying pathogenesis of Von Gierk's (Type I) disease?
glucose-6-phosphatase deficiency (can't go from G6P to Glucose)
Oops!
Check
Okay!
Check
seesaw
Swap points!
Oops!
fairy
Take points!
5
10
15
20
25
fairy
Take points!
5
10
15
20
25
thief
Give points!
5
10
15
20
25
15
What are common symptoms of anemia you see in patients with CML?
Discuss the TNM classification of malignancy and colorectal cancer
T: extent/size of tumor (how far grown in wall colon-mucosa, muscularis properia, suberosa/serosa); N: spread to nearby lymphs; M: metastasis to distant organs
Oops!
Check
Okay!
Check
15
Why does a person with a G6P deficiency need to eat corn starch?
corn starch is a glucose polymer that is broken down slowly = control glucose levels
Oops!
Check
Okay!
Check
15
What does LMNA code for in and why is it so important in development of progeria?
LMNA codes for Lamina A-protein that acts as scaffolding on the inner side of the nucleus->farnesyl stays on lamina A->piles on=abnormal nuclear envelop
Oops!
Check
Okay!
Check
15
what are 3 drugs that can treat Factor V Leiden and briefly explain their MOA
1. Warfarin-block carboxylation of prothrombin/VII/X & proteins C/S->deactivates Vitamin K; 2. Dabigatran-inhibit thrombin; 3. Rivaroxaban-direct Xa inhibitor
Oops!
Check
Okay!
Check
baam
Lose 5 points!
Oops!
magnet
Take 25 points!
Okay!
shark
Other team loses 20 points!
Okay!
thief
Give points!
5
10
15
20
25
15
How does p53 signaling and senescence interact with aging and progeria?
Discuss the role of factor V in blood clot formation (coagulant) & hemostatic (anticoagulant) regulation
Factor V synthesized in liver; Thrombin activates Factor V-> prothrombin to thrombin; Factor V cofactor aPC to degrade VIII/VIIIA= reduce thrombin formation
Oops!
Check
Okay!
Check
15
Describe the process that leads to microangiopathic hemolytic anemia (schistocyte formation) in TTP
