UNIT 5 SIGS 4-6 | Baamboozle - Baamboozle | The Most Fun Classroom Games!

Mesalamine (5-aminosalicylic acid (5-ASA): drug class, MOA, indication, side effect

Sulfasalazine; inhibit production of inflammatory mediators from both cyclooxygenase & lipoxygenase pathways; induce/remission UC+CD; sulfonamide toxicity

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Describe specific dietary modifications and medicinal foods (soy, green tea, flax, olive oil) for dyslipidemia.

soy-reduces HMG-CoA reductase; Green Tea Extract and Green Tea-reduces FA gene expression, inhibits HMG-CoA reductase; flax-reduce LDL

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Describe the immunologic mechanisms resulting in hepatic injury from hepatitis

immune system–mediated cytotoxicity: (HLA) class I–restricted CD8 CTL's recognize hepatitis B core antigen + e antigen on infected hepatocytes->inflammation

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Explain the pathogenesis of dyslipidemia

Primary: Genetic - over production/defective LDL or over-clearance HDL; Secondary: lifestyle + other factors -high free fatty acids + high VLDL =excessive fats

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Identify the utility of serologic and endoscopic evaluation in the diagnosis and management of celiac disease.

Serology: Anti-TTG; Endoscopic-histologically see vilious atrophy+crypt hypertrophy+increased IEL

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Discuss the Batts-Ludwig grading and staging criteria

Grade-amount of necroinflammatory activity; Stage-amount of fibrosis

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Explain the pathogenesis of hepatitis C virus

human reservoir→transmission by blood, semen, in utero→infects hepatocytes→immune response by CTLs kills infected hepatocytes=acute hepatitis

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Explain the pathogenesis of hepatitis B virus

transmitted by blood/sexual contact/transplacentally->hepatocytes->dsDNA->mRNA viral proteins->dsDNA packaged->viral antigens attached by CTL-> acute hepatitis

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In celiac disease, explain how malabsorption can result in osmotic diarrhea

damaged villi + mucosa --> Osmotic diarrhea=osmotically active, poorly absorbed solutes in the bowel lumen->inhibit normal water + electrolyte absorption

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lifesaver

Give 25 points!

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magnet

Take 15 points!

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gift

Win 10 points!

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banana

Go to last place!

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monster

Reset all scores!

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seesaw

Swap points!

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fairy

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thief

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Identify the spectrum of disorders of NAFLD

NAFD --> NASH --> Fibrosis --> Cirrhosis

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Explain how hepatocellular oxidative injury can result in hepatic inflammation and necrosis

Reactive oxygen species produced in mitochondria + ER of hepatocytes via cytochrome P450-> imbalance oxidants/antioxidants=structural & functional abnormality

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Describe the role of gliadin, zonulin, and tight junctions in maintenance of the intestinal barrier

Zonulin regulate tight junctions leakiness; Tight junctions regulate paracellular movement; gliadin modifies paracellular permeability

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Describe the pathophysiology, risk factors, and clinical features of celiac disease

genetic(HLA DQ 2,8)+exposure to prolamins->TTG alter + gliadin w/ zonulin -> IgA against TTG + tight junctions open = inflammation GI ->malabsorption-diarrhea

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thief

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