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15
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Describe the clinical presentation of rheumatoid arthritis.
Swelling and pain in MCP and PIP (DIPs are preserved); morning stiffness 30+ minutes; symmetrical; positive rheumatoid factor, elevated ESR and CRP
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seesaw
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star
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fairy
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25
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baam
Lose 10 points!
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15
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Characterize Borrelia burgdoferi (structure, physiology, epidemiology, mode of transmission).
Spirochete, flagella, outer surface proteins (virulence factor), U.S., Canada, Europe; Ixodes tick vector
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15
×
Explain the delayed onset of symptoms following exposure to Toxicodendron species.
Due to the time that it takes to activate and recruit T cells to the site
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15
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Relate the laboratory testing modalities utilized in the diagnosis and monitoring of systemic lupus erythematosus to its pathophysiology.
+ direct Coombs test: antibodies acting against RBC; renal biopsy: lupus nephritis management; autoantibodies: contribute to meeting diagnostic criteria
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15
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Describe and justify the two-tiered serologic testing for diagnosing Lyme Disease
EIA or IFA -> (positive) -> IgM and IgG Western blot (30- days) OR IgG Western Blot (30+ days); cross reaction --> false positive
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eraser
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rocket
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rocket
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thief
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15
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Describe the signs/symptoms of cryptococcus neoformans infection and explain why flucytosine is used in combination with liposomal amphotericin B.
Lungs: cough, SOB, CP, fever; Brain: headache, fever, N/V, neck pain, photosensitivity; synergistic for more aggressive treatment of cryptococcal meningitis
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15
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Name OMT techniques to treat acute otitis media and state why this is effective.
Galbreath, auricular drainage, lymphatic pump; Promotes drainage of lymph to decrease pathogen proliferation
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15
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Explain why antihistamines are NOT an effective treatment for Toxicodendron dermatitis.
The itching is not caused by histamine release; the itching sensation is due to other granules that are released.
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15
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Characterize the clinical presentation of SLE.
increased anti-DNA antibodies, decreased complement levels, malar (butterfly) rash, alopecia, discoid rash (chronic, scaring), arthralgia, myalgia
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15
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Discuss the role of haptens, including urushiol, in the immune response (priming of T cells).
Small, enter skin -> bind self-proteins -> Langerhans recognizes & goes to lymph-> MHC-II binds -> TH1 release IL2 -> release IFN -> macrophage -> inflammation
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15
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Explain the benefits associated with folic acid supplementation during methotrexate therapy.
Supplemental folic acid helps to alleviate the adverse effects of dihydrofolate reductase inhibition
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banana
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star
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rocket
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banana
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monster
Reset all scores!
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star
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shark
Other team loses 5 points!
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thief
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15
×
Characterize the serologic workup for rheumatoid arthritis
RF= IgM rheumatoid antibody binds modified IgG; ACPA= anti-citrullinated peptide antibodies; ESR= correlates w/ disease activity; CRP= objective measure
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