Unit 4 SIGS cases 1-6 | Baamboozle - Baamboozle | The Most Fun Classroom Games!

Evaluate the pathogenesis and risk factors of autoimmune disease, including heritable and environmental factors. (SLE)

genes & triggers -> anti-nuclear antibody, antigen-antibody complexes -> basement membrane -> complement cascade -> inflammation & hypocomplementemia

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Describe the signs and symptoms of Lyme disease.

1. erythema migrains (target rash), flu-like symptoms 2. bilateral Bell's palsy, AV nodal block 3. arthritis , encephalopathy

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Most common bacterial and viral pathogens causing acute otitis media in children?

Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis

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seesaw

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fairy

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lifesaver

Give 20 points!

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heart

Other team wins 20 points!

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gold

Win 50 points!

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gift

Win 25 points!

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baam

Lose 15 points!

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Characterize the serologic workup for rheumatoid arthritis

RF= IgM rheumatoid antibody binds modified IgG; ACPA= anti-citrullinated peptide antibodies; ESR= correlates w/ disease activity; CRP= objective measure

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Explain how the immune response induces skin changes (vesicles and bullae) in type IV hypersensitivity reactions.

activated T lymphocytes-> (1) release cytokines, inflammation & macrophage activation (2) T cell-mediated cytotoxicity -> ROStissue damage-> skin changes

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Describe the clinical presentation of rheumatoid arthritis.

Swelling and pain in MCP and PIP (DIPs are preserved); morning stiffness 30+ minutes; symmetrical; positive rheumatoid factor, elevated ESR and CRP

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Characterize the clinical presentation of SLE.

increased anti-DNA antibodies, decreased complement levels, malar (butterfly) rash, alopecia, discoid rash (chronic, scaring), arthralgia, myalgia

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fairy

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Discuss the role of haptens, including urushiol, in the immune response (priming of T cells).

Small, enter skin -> bind self-proteins -> Langerhans recognizes & goes to lymph-> MHC-II binds -> TH1 release IL2 -> release IFN -> macrophage -> inflammation

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Describe the signs/symptoms of cryptococcus neoformans infection and explain why flucytosine is used in combination with liposomal amphotericin B.

Lungs: cough, SOB, CP, fever; Brain: headache, fever, N/V, neck pain, photosensitivity; synergistic for more aggressive treatment of cryptococcal meningitis

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Characterize Borrelia burgdoferi (structure, physiology, epidemiology, mode of transmission).

Spirochete, flagella, outer surface proteins (virulence factor), U.S., Canada, Europe; Ixodes tick vector

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Diagnostic tests to differentiate and identify bacterial and viral causes of acute otitis media.

oxidase, catalse, nitrate reduction, butyrate esterase, Blood/chocolate agar, gram stain

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Describe the CCR5 co-receptor tropism of certain HIV strains.

tropism= gp120 complex binds CXCR4 (T cell infection only) OR CCR5 (T cell or macrophage infection) OR can bind both (dual tropism); assay determines type

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Explain the delayed onset of symptoms following exposure to Toxicodendron species.

Due to the time that it takes to activate and recruit T cells to the site

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