Unit 4 SIGS cases 1-6 | Baamboozle - Baamboozle | The Most Fun Classroom Games!

Name OMT techniques to treat acute otitis media and state why this is effective.

Galbreath, auricular drainage, lymphatic pump; Promotes drainage of lymph to decrease pathogen proliferation

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boom

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magnet

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fairy

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thief

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Evaluate the pathogenesis and risk factors of autoimmune disease, including heritable and environmental factors. (SLE)

genes & triggers -> anti-nuclear antibody, antigen-antibody complexes -> basement membrane -> complement cascade -> inflammation & hypocomplementemia

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Explain how methotrexate relieves symptoms of rheumatoid arthritis

mimics folate and blocks synthesis of tetrahydrofolate (inhibits dihydrofolate reductase)-> reduces pain & swelling

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Describe the CCR5 co-receptor tropism of certain HIV strains.

tropism= gp120 complex binds CXCR4 (T cell infection only) OR CCR5 (T cell or macrophage infection) OR can bind both (dual tropism); assay determines type

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Why are clavulanate and amoxicillin used to treat acute otitis media?

Clavulanate is synergistic with amoxicillin to prevent degradation by beta-lactamase

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Characterize the clinical presentation of SLE.

increased anti-DNA antibodies, decreased complement levels, malar (butterfly) rash, alopecia, discoid rash (chronic, scaring), arthralgia, myalgia

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Explain the benefits associated with folic acid supplementation during methotrexate therapy.

Supplemental folic acid helps to alleviate the adverse effects of dihydrofolate reductase inhibition

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Relate the laboratory testing modalities utilized in the diagnosis and monitoring of systemic lupus erythematosus to its pathophysiology.

+ direct Coombs test: antibodies acting against RBC; renal biopsy: lupus nephritis management; autoantibodies: contribute to meeting diagnostic criteria

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Other team wins 25 points!

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rocket

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shark

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banana

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Explain why antihistamines are NOT an effective treatment for Toxicodendron dermatitis.

The itching is not caused by histamine release; the itching sensation is due to other granules that are released.

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Diagnostic tests to differentiate and identify bacterial and viral causes of acute otitis media.

oxidase, catalse, nitrate reduction, butyrate esterase, Blood/chocolate agar, gram stain

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Discuss the role of haptens, including urushiol, in the immune response (priming of T cells).

Small, enter skin -> bind self-proteins -> Langerhans recognizes & goes to lymph-> MHC-II binds -> TH1 release IL2 -> release IFN -> macrophage -> inflammation

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Describe and justify the two-tiered serologic testing for diagnosing Lyme Disease

EIA or IFA -> (positive) -> IgM and IgG Western blot (30- days) OR IgG Western Blot (30+ days); cross reaction --> false positive

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baam

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gold

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rocket

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baam

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Characterize the serologic workup for rheumatoid arthritis

RF= IgM rheumatoid antibody binds modified IgG; ACPA= anti-citrullinated peptide antibodies; ESR= correlates w/ disease activity; CRP= objective measure

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