Describe the bone marrow histopathologic changes in visceral leishmaniasis (reference pancytopenia)
amastigotes=Infected macrophages via reticuloendothelial->bone marrow suppression->Not good immune response->uncontrolled parasite dissemination->pancytopenia
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10
Discuss the laboratory tests that guide antiretroviral drug selection: HLA-B5701 & HIV resistance tests
Haplotype test: assessing the rate of HIV progression; genotype: drug resistance+correct therapy; HLA-B5701 don't use Abacavir drug
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10
PPSV23 - type vaccine, components, dosing
inactivated polysaccharide conjugate, 23 serotypes, T-cell independent to dependent, adults>65; ages 2-64 with conditions; 2 doses/5 years apart
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10
For CVID, what Immunoglobulin assay results are low - IgA, IgG, IgM? and what do low values mean?
low IgG, low IgA and/or low IgM levels; shortage of these antibodies makes it difficult for people with this disorder to fight off infections)
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10
use of TMP-SMX to treat Pneumocystis jirovecii; why is it an opportunistic infection in late HIV
inhibits dihydropteroate synthase+dihydrofolate reductase; PCP lacks ergosterol->antimycotic ineffective; Opportunistic infection in HIV CD4 low=AIDS defining
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10
Describe the Ann Arbor staging system used in staging Hodgkin lymphomas and the prognostic significance.
Hodgkin: contiguous lymph spread but NOT Non-Hodgkin; Ann Harbor I-IV (lymph spread increases+organ involved) + A (no b symptoms) B (yes B sympt)->IVB is worst
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10
Describe the significance for PET-CT for the staging of malignancy.
Evaluate the spread of the cancer; Also see how successful the treatment is for the cancer.
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10
Describe the effect HIV has on CD4+ T-cells.
HIV ->CD4 TH17 (activate neutrophils/protect mucoepithelium) is depleted->decrease CD4 T-> decrease TH1->not enough CD8T = infection + no control of infections
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10
Differentiate between acquired and primary immune deficiency
Primary: result of genetic defects; Secondary: environmental factors - HIV
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10
Compare Hodgkin Lymphoma with Non-Hodgkin Lymphoma