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eraser
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shark
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5
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what do CD4+ helper T cells release?
cytokines
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5
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Define Type II hypersensitivity reaction
cytotoxic reaction mediated by IgG or IgM antibodies
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what is the offending allergen in Toxicodendron?
Urushiol oil
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What is the most common cause of contact dermatitis?
Toxicodendron dermatitis
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What caused the bullae to develop in Toxicodendron Dermatitis?
CD8 T cells caused keratinocyte apoptosis->loss cellular adhesion->spongiosis->papule->bullae/vesicle
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How do you prevent toxicodendron dermatitis?
Wear protective clothing, heavy gloves while gardening, washing contaminated clothes
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What is the elicitation phase in allergic contact dermatitis?
Re-exposure to haptens->type IV hypersensitivity reaction-> sensitized Tcells circulate to skin where antigen is
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Define type IV Hypersensitivity reaction
delayed cell-mediated immune reaction; involves T cells (CD4 or CD8) with antigens
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Do CD8+ killer T-cells recognize MHC I or II?
MHC I
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lifesaver
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fairy
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banana
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What do macrophages release that cause changes in the skin and what changes do we see?
proinflammatory cytokines (TNF, IL-1, IL-6) --> leaky endothelial barrier = edema + redness
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seesaw
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gift
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fairy
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lifesaver
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how do you diagnose toxicodendron dermatitis?
Clinically by look of skin and by HPI from patient but no need for special testing (skin test)
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monster
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shark
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rocket
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lifesaver
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Why is an oatmeal bath a good treatment for Toxicodendron dermatitis?
Colloidal oatmeal binds to your skin and forms a protective barrier; helps hold in moisture and ease inflammation
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