UNIT 3 | Baamboozle - Baamboozle | The Most Fun Classroom Games!

Identify common risk factors for breast cancer

genetics (BRCA1/2, HER2); Demographics (female, older); prolonged estrogen exposure; Previous cancers/radiation; Lifestyle (alcohol, BMI, smoking)

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Describe different screening and diagnostic test for colorectal cancer

Physical exam, digital rectal exam, Fecal Occult (stool based tests), Colonoscopy

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What are common radiological findings in Ewing Sarcoma?

Interrupted periosteal reaction; Moth-eaten bone destruction; ill-defined border; soft tissue mass accumulation around bone tumor

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Describe the clinical features of TTP

Purpura, Confusion, Arrhythmia, Proeinuria, increase serum indirect bilirubin + LDH, decrease haptoglobin

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Why does a person with a G6P deficiency need to eat corn starch?

corn starch is a glucose polymer that is broken down slowly = control glucose levels

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Describe the process of plasmapheresis

liquid part of the blood, or plasma, is separated from the blood cells. Typically, the plasma is replaced with another solution--> returned to body

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What will the lab findings be for a patient with vWF disease and why: Bleeding time, PT, aPTT

Bleeding time- prolonged (impaired platelet plug formation; PT: normal (extrinsic fine); aPTT: prolonged (reduced VII->impaired intrinsic)

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Explain the main 3 factors in the pathophysiology behind Normocytic Anemia (where does TTP, HS, SCD fit within a factor)

1. Defects in RBC environment (TTP); 2. Defects in RBC membrane (HS); 3. Defects in RBC internal contents (SCD)

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Explain the significance of elevated LDH and Uric acid in the presentation of CML

LDH: high turn over of cells-excess cell lysis; Uric Acid-breakdown of cellular nucleic acid contents of leukemia cells

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What are foamy macrophages and their role in FH?

Lipoproteins sequestered -> pro inflammatory -> phagocytes -> cholesterol -> foamy = LDL filled macrophage

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Describe typical characteristics of a peripheral blood smear in a CML patient

leukocytosis, thrombocytosis, myleocytes, neutrophils

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Differentiate the causes and inheritance patterns of the major types of vWD (Type 1, 2, 3)

Type 1: partial deficiency-quantity, autosomal dominant; Type 2: qualitative variant, AD/some AR; Type 3-severe quantitative-missing vWF, Autosomal Recessive

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Outline the steps of a clinical breast exam

Inspection (skin, nipples, retraction views); palpation (vertical strip pattern, nipple, areola); Lymph nodes (supra/infra clavicular, axillary)

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