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Sigs Unit 3 Part 1

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How does p53 signaling and senescence interact with aging and progeria?

DNA damage->lamina disrupted->chromatin conformation distress->increase p53 signaling->increase cell/tissue senescence= accelerated aging

What does LMNA code for in and why is it so important in development of progeria?

LMNA codes for Lamina A-protein that acts as scaffolding on the inner side of the nucleus->farnesyl stays on lamina A->piles on=abnormal nuclear envelop

Describe the process that leads to microangiopathic hemolytic anemia (schistocyte formation) in TTP

TTP->ADAMTS13 deficient->cleavage down, increase vWG multimers->hypercoagubale->prothombotic->aggregate->obstruct vessel->sheering RBCS=shistocytes

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