• UNIT 3 Sigs Part 2
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  • Why is there an increase in serum lactate acid in infants with Von Gierk's disease
    glucose-6-phosphate is also the substrate for glycolysis and produces lactate
  • What are foamy macrophages and their role in FH?
    Lipoproteins sequestered -> pro inflammatory -> phagocytes -> cholesterol -> foamy = LDL filled macrophage
  • Describe the pathophysiology of FH
    Elevated LDL at birth due to lack of LDL clearance from plasma (absent/disorder LDL receptors)
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