Unit 6b SIGs Cases 6.8a-6.10a

Help

Explain the physiologic basis of protein handling in the kidney. (SIGS6.8a)

GFB-> fenestrated capillaries, BM (heparin sulfate; charge barrier)-> podocytes (nephrin; size & charge); destruction= proteinuria

Explain how alterations in components of the filtration barrier would result in hematuria and proteinuria (and define proteinuria). (SIGS/LGS 6.8a)

Proteinuria (>300 (Slater)): podocyte damage-> impaired charge barrier-- NEPHROTIC; Hematuria: glomerular inflam-> GBM damage-> loss of RBC to urine-- NEPHRITIC

Describe the anatomical and physiological features of the glomerulus. (SIGS6.8a)

afferent arteriole, efferent arteriole, mesangial cells & matrix, fenestrated endothelium, GBM, podocytes, Bowman's capsule; size & charge barriers

Unlock this slideshow and over 4 million more with Baamboozle+

Try slideshows