Explain how insulin resistance can lead to the development of hepatic steatosis
skeletal resistance -> glucose to liver; adipose resistance -> lipolysis = glycerol + Fatty acids -> fats deposited in liver
Explain how hepatocellular oxidative injury can result in hepatic inflammation and necrosis
Reactive oxygen species produced in mitochondria + ER of hepatocytes via cytochrome P450-> imbalance oxidants/antioxidants=structural & functional abnormality
Identify common comorbidities of NAFLD
hepatic manifestation of metabolic syndrome linked with insulin resistance; obesity, dyslipidemia, diabetes
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