Compare normal movement of ions and nutrients across intestinal epithelium to that of secretory diarrhea.
Water is absorbed on osmotic gradient; water follows solute. Secretory diarrhea: solute (such as Cl-) secreted into lumen--> water follows--> diarrhea
What are the most common causative agents of traveler's diarrhea?
Enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni, Shigella spp., Salmonella spp., other E. coli strains
Describe the MOA of loperamide and bismuth compounds.
Loperamide: binds peripheral mu in enteric NS--> slow colonic transit (no BBB); Bismuth: salicylate inhibits intestinal prostaglandin and Cl- secretion
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