• Rheumatoid arthritis
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  • What is the most dominant cytokine in RA?
    - TNF-alpha – potent paracrine inducer of other pro-inflammatory cytokines
  • Primary site of RA
    - Synovium
  • The presence of what genes may give you a genetic predisposition to RA?
    - HLA – DR1 or HLA-DR4
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