What is the dark, course granulation in the neutrophils?
The granulation observed is toxic granulation. This disorder is commonly seen in the hematology laboratory.
Does this condition alter the phagocytic effectiveness of the leukocytes?
No. Toxic granulation is believed to represent the precipitation of ribosomal RNA due to metabolic toxicity occurring in the cell
What is the most probable explanation of the patient’s elevated leukocyte count?
Toxic granulation can be observed in granulocytes in a variety of conditions, including severe infections, burns, and drug therapy.