He was fired from the Kansas City Star because his editor felt he "lacked imagination and had no good ideas", he went on to make movies such as 'Snow White' and 'Cinderella'.
Walt Disney
He was rejected by the University of Southern California of Cinematic Arts multiple times, later to create Jaws, Jurassic Park and E.T..
Steven Spielberg
As a child he had some difficulty communicating and learning in a traditional manner, but became the greatest physicist and developed the theory of relativity.
Albert Einstein