although in spite of

Our new neighbors are quite nice _______ they are sometimes talkative. (A. despite B. in spite of C. though D. as though)

_______ of the difficulty, they managed to climb to the top of the mountain. (A. In spite B. Despite C. But D. Although)

_____________, he could not finish the job. (A. As hard as he work B. Despite he worked hard C. Though he worked hard D. Although hard work)

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