UNIT 3 Sigs Part 2 | Baamboozle - Baamboozle | The Most Fun Classroom Games!

Describe the pathophysiology of FH

Elevated LDL at birth due to lack of LDL clearance from plasma (absent/disorder LDL receptors)

Oops!

Check

Okay!

Check

In reference to anabolic and catabolic, what is Glycogenesis? What is Glycogenolysis?

Glycogenesis - anabolic (create glycogen to be stored); Glycogenolysis- catabolic (break down glycogen to useable glucose)

Oops!

Check

Okay!

Check

thief

Give points!

gift

Win 25 points!

Okay!

gift

Win 15 points!

Okay!

lifesaver

Give 20 points!

Oops!

What is the most distinguished clinical feature you would see on a patient with FH?

Xanthomas

Oops!

Check

Okay!

Check

Describe typical characteristics of a peripheral blood smear in a CML patient

leukocytosis, thrombocytosis, myleocytes, neutrophils

Oops!

Check

Okay!

Check

Explain the role of parvovirus B19 in the development of acute anemia (aplastic) crisis with chronic spherocytosis

Parvovirus infects and destroys RBC progenitors in the bone marrow, can halt production of RBCs for 1-2 weeks until immune system controls the infection

Oops!

Check

Okay!

Check

Discuss the process of melanoma cancer from a Benign nevus to Metastatic melanoma (mentioning skin layers or biologic events)

Benign nevus (epidermis)->Dysplastic nevus (basement membrane)->radial growth (dermis)->vertical growth (dermis)->metastatic (lung/liver/brain)

Oops!

Check

Okay!

Check

Describe the general appearance of cutaneous melanoma with the ABCDE criteria

A: Assymetrical; B: blurry border; C: more than 1 color; D: diameter>6mm; E: evolution of mole sudden change in shape/size/color

Oops!

Check

Okay!

Check

why do we treat sickle cell disease with Hydroxyurea?

increases fetal hemoglobin to retard gelation and sickling of RBCs

Oops!

Check

Okay!

Check

Explain the mechanism behind the APC/β-catenin pathway in the development of colorectal cancer

Loss APC function->β-catenin accumulates->complex w DNA->increases MYC->proliferation

Oops!

Check

Okay!

Check

boom

Lose 50 points!

Oops!

seesaw

Swap points!

Okay!

gift

Win 15 points!

Okay!

baam

Lose 5 points!

Oops!

Explain the rationale for use of HMG-CoA reductase inhibitors in the management of FH

inhibit conversion HMG-CoA to Mevalonate-> reduce cholesterol uptake ->increase synthesis LDL hepatic receptors ->re-uptake LDL = decrease plasma LDL

Oops!

Check

Okay!

Check

eraser

Reset score!

Oops!

gold

Win 50 points!

Okay!

fairy

Take points!

thief

Give points!

Pertinent physical exam findings in progeria

alopecia, prominent scalp pain, skin discoloration, reduced subcutaneous adipose tissue, abnormal dentition, beaked nose,

Oops!

Check

Okay!

Check

What is the role of CD99 stain in developing diagnosis in Ewing Sarcoma?

Cell-surface transmembrane protein that is highly expressed in Ewings Sarcoma

Oops!

Check

Okay!

Check

What are foamy macrophages and their role in FH?

Lipoproteins sequestered -> pro inflammatory -> phagocytes -> cholesterol -> foamy = LDL filled macrophage

Oops!

Check

Okay!

Check

Restart Join for Free

Your experience on this site will be improved by allowing cookies.