It was the only effective malaria remedy for 300 years.

sailed around South America and landed on the island of Guam

a person who holds beliefs different from the teachings of the Catholic Church

Ten to fifteen percent of enslaved people died of disease or despair during the voyage

Spanish-born people and Creoles

persecute

a Spanish conqueror who sought gold and other riches in the Americas

His travel writings suggested that there could be riches north of New Spain.

South America was a huge landmass.

Countries had exclusive rights to trade with the goods from their own colonies. The more colonies a country had, the more wealth it would accrue.

an area of land that includes a particular river or lake and all the bodies of water that flow into it

a protection against disease, either natural or induced by vaccination