Describe the morphologic appearance of the RBC's given the following result. RBC: 1.89; 7.5 g/dL; Hct 21.0%; RDW 18.5
Macrocytosis with anisocytosis The red cell indices are calculated as follows: MCV = (7.5/1.89) Ã 10 = 111 fL; mean cell hemoglobin (MCH) = (7.5/1.89) Ã 10
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15
What is an acquired condition that interferes with porphyrin synthesis, Chronic exposure may reveal microcytic, hypochromic clinical picture, and can lead to Sideroblastic anemia?
Lead poisoning Lead poisoning is not only an example of acquired Sideroblastic anemia but also of an acquired porphyria. Chronic exposure to to lead may re
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15
What allows for early relase of reticulocytes from the bone marrow, prevents apopttic cell death, is released in response to low oxygen, is synthesized in the kidney and reduces the time needed for cells to mature in the bone marrow.
Erythropoietin (Fun fact: Anemia of Chronic Kidney disease is caused from a lack of EPO)
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15
What would be increased with Anisocytosis?
RDW The red cell histogram is wider than normal. RDW is used along with the mean cell volume (MCV) to morphologically classify anemias.
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15
Macrocytic nonmegaloblastic anemia may be found in:
Liver disease The anemia found in liver disease is macrocytic, but it is not megaloblastic. The large red cells result because of membrane changes resultin
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15
IDA is Microcytic (T/F)
Iron deficiency anemia is microcytic and iron deficiency is the most common cause of microcytosis. Vitamin B 12 deficiency is macrocytic; sickle cell anemia an
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15
The mononuclear cphagocytes can be found in all tissues and are part of the immune system.
Macrophages
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15
What are large and bluer on Wright stain from remanat ribonucleic acid (RNA? Stains with NMB, assess the bone marrow's ability to increase RBC production defect or premature hemolysis and shortened survival defect.
Reticulocytes
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15
The best definition of anemia is a _________ hemoglobin, hematocrit, and red cell count compared with typical results for healthy people in the same demographic group.
Decreased The best definition of anemia is a decreased hemoglobin, hematocrit, and red cell count compared with typical results for healthy people in the
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15
Which of the following is comprised of denatured hemoglobin?
Heinz body Basophilic stippling: Precipitated ribonucleic acid (RNA) Pappenheimer body: Ferric nonheme iron Heinz body: Denatured hemoglobin Howell-Jolly b
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15
A ovalocyte shape of red cell is described as a round, dense cell with no area of central pallor (T/F)
False a spherocyte is the shape of red cell is described as a round, dense cell with no area of central pallor
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15
Hypersegmented neutrophils can be found in...............
Megaloblastic Anemia Folate deficiency is thought to cause megaloblastic anaemia by inhibiting thymidylate synthesis, which is required for DNA prod
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15
In the case of massive blood loss, the anemia would have a morphologic classification of normochromic, normocytic. (T/F)
True When anemia develops slowly (chronic), the body is able to make a number of compensations so that the patient may have few if any symptoms (ie IDA).
